In his latest "Ask Me Anything" episode, Matt is once again joined by Dr. Eti Ben Simon to respond to a variety of audience questions, beginning with the role of AI in sleep medicine. Together, they explore how AI is currently being used to improve the accuracy and efficiency of sleep stage scoring, and how it shows promise in diagnosing sleep apnea and personalizing treatment plans. Matt highlights the potential for AI to integrate with smart home technology and predict an individual's risk of developing sleep disorders based on genetics, lifestyle, and environmental data. He also discusses the development of AI-driven therapeutic interventions like digital therapists and brain-computer interfaces to modulate sleep.

Further responses touch upon the impact of sleep deprivation on ethical decision-making and the unique sleep challenges faced by astronauts in space. Matt and Dr. Ben Simon go on to consider the effects of disrupted circadian rhythms, microgravity, and CO2 buildup on astronauts' sleep quality. Finally, they engage in a playful thought experiment, each sharing their desired sleep superpower, ranging from sleep exchange to insightful dreams that provide instant solutions upon waking.

Tired of untrustworthy protein shakes? Show sponsor Puori prioritizes quality: hormone-free, GMO-free, and pesticide-free. Every batch is third-party tested for 200+ contaminants - you can even scan the QR code for lab results! Matt recommends the addictive dark chocolate flavor with 21g of protein. Ready to experience the Puori difference? Matt’s listeners get 20% off, so visit puori.com/mattwalker today!

Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.

Matt is only too happy to share the fact that launching his sleep-related merchandise sales was incredibly smooth, thanks to show sponsor Shopify and their integrated sales and inventory system. And now, just for you, Shopify is generously offering an exclusive trial at shopify.com/mattwalker. Whether it's online or in-person sales, Shopify simplifies it all. So, be sure to stop in at shopify.com/mattwalker to start your exclusive journey now!

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt on Instagram.

Matt: Instagram @drmattwalker or on X @sleepdiplomat

Eti: X @etoosh, Instagram https://www.instagram.com/eti_bensimon/, or email at etoosh@gmail.com

Welcome back to a new episode of the Matt Walker Podcast, where we revisit the often-discussed topic of catch-up sleep. We delve into the complexities of weekend catch-up sleep, exploring a recent study of 91,000 participants that suggests a potential link between compensatory weekend sleep and a reduced risk of heart disease. While this news offers a glimmer of hope, it's crucial to understand this benefit within the context of existing research. Studies like that of Dr. Ken Wright at the University of Colorado Boulder show weekend catch-up sleep only recovers a small percentage of sleep debt and doesn’t fully reverse the damage of weekday sleep deprivation on other critical bodily systems. We explore the impact of short sleep and weekend catch-up sleep on circadian rhythms, food consumption, blood sugar regulation, and deep sleep. This nuanced perspective emphasizes the importance of prioritizing consistent, sufficient sleep throughout the entire week for optimal health.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

One of our sponsors this week is the biochemical electrolyte drink company LMNT, and they are very kindly offering eight free sample packs when you purchase any one of their orders at drinklmnt.com/mattwalker. LMNT is an electrolyte sports drink that I can get behind - it's created from the basis of science, and it has no sugar, no coloring, and no artificial ingredients – all qualities that are so important to maintaining your blood biochemical balance. If you want to give LMNT a try, just head on over to drinklmnt.com/mattwalker and get your eight free samples with your first purchase.

I have to tell you, launching my sleep-related merchandise sales was incredibly smooth, thanks to our new sponsor Shopify and their integrated sales and inventory system. And now, just for you, Shopify is generously offering an exclusive trial at shopify.com/mattwalker. Whether it's online or in-person sales, Shopify simplifies it all. So, be sure to stop in at shopify.com/mattwalker to start your exclusive journey now!

As a health fanatic, my kryptonite has always been bread. Then I discovered Hero Bread: zero net carbs, zero sugar, and packed with fiber! For years, I've enjoyed their fluffy loaves (my favorite topped with tomatoes, balsamic, and parmesan). Now, you can try it too! Hero Bread offers a delicious variety of healthy bread options, from tortillas and wraps to bagels and dinner rolls. Ready to enjoy bread again? Get 10% off your order at hero.co using code MATTWALKER.

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt on Instagram.

Matt: Instagram @drmattwalker or on X @sleepdiplomat

Matt Walker welcomes Dr. Ranji Varghese to the podcast this week for an in-depth conversation about sleep and prescription sleeping pills. A psychiatrist specializing in sleep medicine, Dr. Varghese begins by discussing his entry into the field which was sparked by a fascination with sleep and wake circadian rhythms. He goes on to highlight the Minnesota Regional Sleep Disorder Center's focus on parasomnias, particularly REM Sleep Behavior Disorder, emphasizing the intersection of neuroscience, physiology, and psychology in sleep medicine.

As you will hear, sleeping pills, prescribed to initiate or maintain sleep, are typically used as a last resort for insomnia after other treatments fail. Dr. Varghese explains they work by modulating brain activity, often targeting neurotransmitters like GABA or melatonin receptors. He details two main classes: benzodiazepines (like Restoril and Ativan) and non-benzodiazepines (Z-drugs like Ambien and Lunesta), outlining their mechanisms, benefits, and risks. His powerful personal anecdote and the discussion of complex sleep-related behaviors underscore the critical need for careful consideration and informed decision-making when using these medications.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

Long-time show sponsor LMNT is Matt Walker’s go-to for a sugar-free electrolyte mix. With the perfect electrolyte balance and science-backed formulation, LMNT is a product Matt trusts daily, adding it to his workouts and protein shakes. And now, for a seasonal twist, their Chocolate Medley range is back with flavors like Chocolate Mint and Matt’s favorite, Chocolate Raspberry. Get a free sample pack with any purchase at drinklmnt.com/mattwalker—just use his link to try it yourself!

Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt on Instagram.

Matt: Instagram @drmattwalker or on X @sleepdiplomat

Connect with Dr. Varghese:
Instagram: @docvarghese
X: @docvarghese

Minnesota Regional Sleep Disorders Center:
https://www.hennepinhealthcare.org/specialty/minnesota-regional-sleep-disorders-center/
IIT-MN: https://iit-mn.com/

Embark on a calming journey to the Scottish Highlands in tonight's sleep story. Join Matt as he guides you through a tranquil landscape of rolling hills, sparkling lochs, and fragrant valleys. Let the soothing sounds of nature and the peaceful imagery lull you into a deep, restful sleep. This immersive experience is designed to ease your mind and help you unwind after a long day.

Tonight's story offers a sanctuary from the whirlwind of everyday life, allowing you to release your worries and embrace the stillness of the night. Feel the gentle ground beneath your feet as you wander along winding paths, breathe in the fresh Highland air, and listen to the distant whisper of a waterfall.

This episode is sponsored by BetterHelp. Just as we prioritize our physical well-being, nurturing our mental health is equally crucial. BetterHelp offers accessible online therapy, connecting you with licensed therapists from the comfort of your home. Visit betterhelp.com/MattWalker for 10% off your first month.

Matt: Instagram @drmattwalker or on X @sleepdiplomat

Dr. Charan Ranganath returns to explore the complexities of human memory with Matt here today. Together, they delve into memory's architecture, examining how sleep, trauma, and AI impact its function. The discussion covers episodic and semantic memory, emphasizing the role of sleep in memory consolidation and challenging the traditional "archive" model with Dr. Ranganath proposing a dynamic web of interconnected associations instead.

The conversation then shifts to trauma's effects, focusing on PTSD and innovative therapeutic approaches—including psychedelics—designed to enhance neural plasticity and reprocess traumatic memories. Nightmares and noradrenaline's role are explored, revealing how understanding memory's mechanisms can lead to better mental health.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

Are sleep troubles keeping you up at night? Matt used to be a skeptic about meditation, but 7 years ago, he tried it using a fantastic meditation app called ‘Calm’, and it transformed his sleep! Now, he meditates for 10 minutes before bedtime every night! He’s also partnered with Calm who have been generous enough to offer his podcast listeners an exclusive 40% discount on their premium subscription! All you have to do is go to calm.com/mattwalker and take advantage of this incredible deal! Head on over now and improve your sleep today!

One of today’s sponsors, 23andMe, provides genetic insights into health and sleep, and Matt, who has used it for eight years to understand genetic risks, is impressed by their sleep-focused data. With details on chronotype—whether you’re genetically more inclined to be a morning person or night owl—along with insights on sleep quality, depth, and insomnia risk, 23andMe’s reports offer valuable understanding of your unique sleep patterns. Explore your sleep genetics at 23andMe.com/MattWalker for 10% off your service. Total Health membership includes services initiated and performed by third-party clinicians and lab providers through the 23andMe platform. Additional terms and conditions also
apply. See 23andme.com to learn more. Total Health Membership not available to residents of HI, NJ, NY, RI and US territories. Check with your FSA/HSA administrator to confirm eligibility.

Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt on Instagram.

Matt: Instagram <

Matt and Eti’s latest AMA episode begins with an exploration of the fascinating relationship between circadian rhythms and medication effectiveness. Discover how this internal 24-hour clock influences drug absorption, distribution, metabolism, and excretion, impacting treatment outcomes. The episode then delves into chronotherapy, revealing how timing can optimize medication efficacy and minimize side effects for conditions like high cholesterol and high blood pressure.

Together, our hosts investigate whether individuals thriving on minimal sleep have a genetic advantage, focusing on the DEC2 gene variant. Additionally, the episode unravels the evolutionary basis of biphasic and segmented sleep, and examines the gut microbiome’s role in sleep regulation, discussing how gut health interventions like probiotics may improve sleep. They go on to explore diverse sleep needs across animal species, gaining insights into sleep's adaptability and importance, and finish up by addressing whether catching up on sleep is truly feasible, analyzing research on sleep deprivation and recovery. Tune in to enhance your understanding of sleep and its profound impact on health.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

Looking for comfort and style in your wardrobe? While fashion isn’t his expertise, Matt found the perfect fit with SKIMS— a proud sponsor of the show - thanks to his better half’s recommendation. Known for their breathable, soft fabrics, SKIMS delivers the comfort Matt values most. Try SKIMS yourself and feel the difference! Visit skims.com, select “Podcast” at checkout, and choose "The Matt Walker Podcast" from the dropdown. Plus, explore their new holiday shop—just in time for the season!

Long-time show sponsor LMNT is Matt Walker’s go-to for a sugar-free electrolyte mix. With the perfect electrolyte balance and science-backed formulation, LMNT is a product Matt trusts daily, adding it to his workouts and protein shakes. And now, for a seasonal twist, their Chocolate Medley range is back with flavors like Chocolate Mint and Matt’s favorite, Chocolate Raspberry. Get a free sample pack with any purchase at drinklmnt.com/mattwalker—just use his link to try it yourself!

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt on Instagram.

Matt: Instagram @drmattwalker or on X @sleepdiplomat

Eti: X @etoosh, Instagram https://www.instagram.com/eti_bensimon/, or email at etoosh@gmail.com

Join Matt today as he explores the fascinating intersection of sleep, metabolism, and weight management, delving into the science of dual orexin receptor antagonists (DORAs). This episode dissects a groundbreaking study on suvorexant (Belsomra), an FDA-approved insomnia medication, and its potential to enhance fat burning during sleep. Matt unpacks the role of orexin, a neuropeptide crucial for wakefulness, and explains how DORAs work by targeting orexin receptors to promote natural sleep.

This preliminary research, conducted on healthy young men, reveals suvorexant's intriguing ability to not only improve sleep quality, but also increase fat oxidation while preserving muscle mass. While these initial findings are promising, Matt emphasizes the importance of cautious optimism and the need for further research in more diverse groups. He explores the implications for weight management and metabolic health, highlighting the potential of suvorexant as a novel approach to weight loss. However, Matt underscores that a holistic approach, including diet, exercise, and good sleep hygiene, remains essential for long-term success. Tune in today to gain valuable insights into the complex relationship between sleep and metabolism, and how scientific advancements may pave the way for innovative solutions in weight management.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

Are sleep troubles keeping you up at night? Matt used to be a skeptic about meditation, but 7 years ago, he tried it using a fantastic meditation app called ‘Calm’, and it transformed his sleep! Now, he meditates for 10 minutes before bedtime every night! He’s also partnered with Calm who have been generous enough to offer his podcast listeners an exclusive 40% discount on their premium subscription! All you have to do is go to calm.com/mattwalker and take advantage of this incredible deal! Head on over now and improve your sleep today!

Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt on Instagram.

Matt: Instagram @drmattwalker or on X @sleepdiplomat

Escape the everyday and drift off to dreamland with Matt’s guided sleep story. Together, we'll journey through tranquil landscapes, from moonlit valleys to sun-dappled forests, letting the soothing sounds and imagery lull you into a peaceful slumber. This is a sleep story designed to ease your mind and gently guide you into a deep, restful sleep. If you find yourself struggling to unwind after a long day, allow this narrative to transport you to a place of tranquility and calm. Release your worries and embrace the stillness of the night as we embark on this relaxing journey together.

This episode is sponsored by BetterHelp. Just as we prioritize our physical well-being, nurturing our mental health is equally crucial. BetterHelp offers accessible online therapy, connecting you with licensed therapists from the comfort of your home. Visit betterhelp.com/MattWalker for 10% off your first month.

Matt: Instagram @drmattwalker or on X @sleepdiplomat