Some people hit walls. Others knock them down, build a lab, raise millions, and call up strangers to make a genetically engineered mouse. When Terry Pirovolakis learned his young son Michael had SPG50 — a rare degenerative disease with no treatment and a grim prognosis — he didn’t spiral. He mobilized. In this jaw-dropping story of parental devotion and scientific hustle, Terry recounts how he went from IT consultant to biotech trailblazer, spearheading the development of a gene therapy from scratch. From homemade mice to confronting the Prime Minister, this episode is a whirlwind of heartbreak, grit, global collaboration, and unshakable hope. It’s not just about saving one child — it’s about lighting a path for thousands more.

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Alex hasn’t peed in 17 years — and he’s been busy. Diagnosed at 11 with a rare kidney disease triggered by a brutal run of childhood illnesses, his life became a blur of seizures, dialysis, and a transplant that didn’t stick. Now, between 7-hour nocturnal dialysis sessions, Alex co-owns two thriving Toronto restaurants and is building a creative community from scratch. In this episode, he talks about living with three kidneys (none of them working), how trauma forged his sense of purpose, and why “burnout” takes on a whole new meaning when your body’s already pulling an all-nighter just to keep you alive.

They say laughter is the best medicine - unless you're diagnosed with something that sounds like a meme.

Mike lives with FAP, short for Familial Adenomatous Polyposis - a rare genetic disorder that guarantees colon cancer without drastic surgical intervention. In this unfiltered and laugh-out-loud conversation, Mike opens up about the brutal realities of living without a large intestine, the mental toll of life-altering surgery at 18, and the deeply personal decision to write a memoir titled A Bump in the Road. From rows of shark-like baby teeth to an ostomy bag that looked like Rudolph’s nose, Mike takes us through the gritty details of his medical journey. But what starts as a conversation about disease turns into something much bigger: a story of resilience, perspective, and finding purpose on the other side of pain. Plus, a passionate pitch for bidets, because we all know bidets are for kings.

Check out Mike's book!