Do life-saving statins secretly damage your brain? This episode tackles the controversial link between statins and dementia head-on. I'll explore the origins of the fear, from patient anecdotes to plausible science, and weigh it against the highest-quality evidence from large clinical trials. We'll separate the myths from the facts to reach a clear, evidence-based verdict on how these drugs truly affect your brain.

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Click Here: https://www.jrennickemd.com

CHAPTERS:

00:00 - Intro

01:07 - Where This Idea Came From

04:55 - The Possible Mechanism Cause of Symptoms

07:31 - The Scientific Evidence for Harm

11:20 - The Evidence Against The Claims

14:20 - Putting It All Together: A Unifying Framework

18:57 - Final Thoughts/ Guidance

23:32 - Outro

SELECTED REFERENCES:

https://pubmed.ncbi.nlm.nih.gov/12885101/

https://doi.org/10.4172/2329-6887.1000141

https://www.researchgate.net/publication/362574285_Mendelian_Randomization_Study_of_PCSK9_and_HMG-CoA_Reductase_Inhibition_and_Cognitive_Function

https://pmc.ncbi.nlm.nih.gov/articles/PMC5487843/

https://pmc.ncbi.nlm.nih.gov/articles/PMC5487843/

https://pmc.ncbi.nlm.nih.gov/articles/PMC5487843/

https://pmc.ncbi.nlm.nih.gov/articles/PMC5487843/

https://www.jacc.org/doi/10.1016/j.jacc.2021.04.075

Disclaimer This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

Ever wonder what your blood pressure numbers really mean? With different guidelines from the US and Europe, it can be incredibly confusing. In this episode, I'll cut through the noise, explaining the different standards, how to measure your BP accurately, and what's truly considered "optimal" for your cardiovascular health. We'll break down the authoritative guide on what your numbers really mean for you.

Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life.

➡️ Download Here: https://www.jrennickemd.com/necessaryninepdf

CHAPTERS:
00:00 - Intro
00:47 - Systolic vs Diastolic Blood Pressures
02:04 - How To Measure Blood Pressure
04:17 - Monitoring Blood Pressure Outside the Clinic
06:16 - US Blood Pressure Guidelines
08:15 - Medication Isn’t Always The Answer
09:54 - The European Guidelines
11:41 - Why The Guidelines Differ
14:20 - So What Is “Normal” Blood Pressure?
16:11 - BP Goals for Different Ages
17:49 - Special Considerations for Specific Conditions
19:08 - Why We Actually Care About Blood Pressure
20:39 - The Risks of Low Blood Pressure
22:43 - Lifestyle Interventions for BP Management
24:45 - Medications for BP Management
26:35 - Takeaways
27:03 - Outro

SELECTED REFERENCES:
[https://academic.oup.com/eurheartj/article/45/38/3912/7741010?login=false#503300301](https://academic.oup.com/eurheartj/article/45/38/3912/7741010?login=false#503300301)
[https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.15026](https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.15026)
[https://www.ahajournals.org/doi/10.1161/hyp.0000000000000065](https://www.ahajournals.org/doi/10.1161/hyp.0000000000000065)
[https://iris.who.int/bitstream/handle/10665/344424/9789240033986-eng.pdf](https://iris.who.int/bitstream/handle/10665/344424/9789240033986-eng.pdf)
[https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.124.24173](https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.124.24173)

*Disclaimer*

This podcast is for entertainment, education, and informational purposes only.
The topics discussed should not solely be used to diagnose, treat , or prevent any condition.
The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.
Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

The old "try lifestyle first" model for treating obesity is officially over. For years, we've treated obesity differently than other chronic diseases, often blaming a lack of willpower. In this podcast, I break down the new guidance from the American College of Cardiology and explore why we need to treat obesity as the complex biological disease it is, using powerful new medications synergistically with lifestyle changes right from the start.

Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life.

➡️ Download Here: https://www.jrennickemd.com/necessaryninepdf

CHAPTERS:
00:00 - Intro
00:44 - The Scale of the Problem
02:21 - Diagnosing Obesity
05:19 - How Biology Affects Weight Loss
07:33 - How Lifestyle Only Tends to Fail
10:18 - A New Tool: Medications
11:32 - Effectiveness of Incretin Therapies
13:11 - The SELECT Trial
15:18 - Side Effects
18:24 - The ACC’s New Proposed Model
21:18 - Biggest Issues Preventing Change
23:22 - Takeaways
25:21 - Outro

SELECTED REFERENCES:
Gilbert, O., Gulati, M., Gluckman, T. J., Kittleson, M. M., Rikhi, R., Saseen, J. J., & Tchang, B. G. (2025). 2025 Concise Clinical Guidance: An ACC Expert Consensus Statement on Medical Weight Management for Optimization of Cardiovascular Health. Journal of the American College of Cardiology. [https://doi.org/10.1016/j.jacc.2025.05.024](https://doi.org/10.1016/j.jacc.2025.05.024)

*Disclaimer*

This podcast is for entertainment, education, and informational purposes only.
The topics discussed should not solely be used to diagnose, treat , or prevent any condition.
The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.
Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.