Weight loss medications have dramatically transformed obesity treatment, but there's a surprising trend emerging: many patients who find success on these drugs are stopping them. Why? And what happens next?

Join Holly and Jim as they welcome Dr. Tim Garvey, endocrinologist and Professor of Nutrition and Medicine at UAB, to explore this fascinating paradox. As one of the world's leading experts on weight loss medications who has been involved in clinical trials for both current and next-generation drugs, Dr. Garvey offers insights into why these medications work, why patients discontinue them, and what the future holds for obesity treatment.

Whether you're considering weight loss medications, already taking them, or simply interested in the evolving science of obesity treatment, this episode reveals the complex reality behind today's most talked-about weight management tools and the importance of thinking beyond just weight loss.

• Why these new medications represent a "landmark in the history of medicine" comparable to insulin and penicillin
• The surprising reasons patients stop taking medications that successfully help them lose weight
• What happens to your body when you discontinue weight loss medications
• Why losing "too much weight" can sometimes create unexpected health challenges
• How the medications work—and why they're not "fixing" obesity permanently
• The critical differences between weight loss and weight maintenance medications
• Why many physicians aren't prepared to help patients develop long-term strategies
• The unexpected side effects discovered through clinical trials that nobody anticipated
• What future weight loss medications might look like and how they could change treatment

Have you ever had a burning question about weight loss that you were too embarrassed to ask? Those nagging doubts and confusing contradictions that make you wonder if you're doing something wrong? You're not alone.

In this episode, Holly and Jim tackle the real, unfiltered questions about weight loss that people are often afraid to ask out loud. From mysterious plateaus to stress eating, and yes, even that awkward question about whether sex counts as exercise – they're breaking down the science behind these common confusions with their signature no-BS approach. You'll discover why your body sometimes seems to work against you and, more importantly, what you can actually do about it.

Discussed on the episode:

• Why the scale seems to drop so fast at first, then frustratingly slows down
• The truth about whether your friend really can "eat whatever they want"
• What actually happens to your body when you have that weekend "slip-up"
• The real deal with weight loss medications like Ozempic and Wegovy
• Why stress sends you straight to the cookie jar (and what to do about it)
• The surprising science behind late-night eating
• Whether counting calories is really all that matters
• That awkward question about sex and calorie burning (spoiler: don't cancel your gym membership)
• How alcohol affects your body's fat-burning abilities

Food noise - those persistent thoughts about food that seem to run on an endless loop - has become a hot topic in weight management, especially with the rise of new medications. But what exactly is food noise, and why does it matter for your weight loss journey?

Join Holly and Jim as they dive deep into this topic with Dr. Corby Martin from the Pennington Biomedical Research Center. As a leading expert in ingested behavior and weight management, Dr. Martin has developed the first scientific way to measure food noise - a breakthrough that could transform how we understand and treat problematic eating patterns.

• What food noise really is and why it's different from cravings or hunger
• Why your environment might be "speaking" to you more than you realize
• The unexpected relationship between what you eat and your food-related thoughts
• How lifestyle changes could quiet those persistent food thoughts (even without medication)
• The potential downsides of completely eliminating food noise
• Why your microbiome might be influencing your food choices more than you think
• Real answers to listener questions about sleep, fasting, and appetite
• Simple, actionable steps you can take today to manage food noise

• Development and validation of the Food Noise Questionnaire