Paragon28 is entering the next chapter of foot and ankle surgery by developing enabling technology that customizes the procedure to the patient and eliminates a one-size-fits-all approach, CEO Albert DaCosta tells Bloomberg Intelligence. In this episode of the Vanguards of Health Care podcast, DaCosta sits down with BI analyst Matt Henriksson to talk about how the company started from the co-founder’s basement, how its technology built a cohesive commercial model to aid foot and ankle surgeons, including product and clinical support, and how it has developed the SMART28 ecosystem that gives surgeons the ability to calculate a patient-specific surgical plan focusing on both bone-reconstruction and soft-tissue balancing.

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ViiV Healthcare's Head of R&D, Dr. Kimberly Smith, meets with Bloomberg Intelligence senior analyst John Murphy to discuss the evolution of HIV therapy since the 1990s, what she sees as providing the next steps of treatment innovation and how close science may be to a cure. A wide-ranging discussion in this episode also includes topics such as drug access, pricing and clinical trial diversity.

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"If all goes well, Heartbeat Health will be a household name for the first referral from primary care for cardiology. It'll be easier than everyone else out there and less expensive than other referrals." Dr. Jeff Wessler, CEO and Founder of Heartbeat Health, tells Bloomberg Intelligence in this episode of the Vanguards of Health Care podcast. Dr. Wessler joins BI analyst Jonathan Palmer to discuss the genesis of Heartbeat's decentralized cardiology practice, how the company iterated from a brick and mortar clinic to a virtual platform to speed access, and why keeping patient care at the center has improved outcomes.

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Generate Biomedicines’ proprietary platform aims to use generative biology to upend traditional drug development across therapeutic protein modalities. Gevorg Grigoryan, chief technology officer, and Alex Snyder, chief medical officer, sit down with BI analysts Andrew Galler and Sam Fazeli to discuss the general state of AI in drug development and the unique capabilities of the Generate platform in developing novel biologics.

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AVS aims to redefine intravascular lithotripsy with its Pulse IVL System, which utilizes hydraulics technology to fracture calcified lesions and expand the diseased vessel with a single device, executive chair Mark Toland explains to Bloomberg Intelligence. In this Vanguards of Health Care episode, Toland sits down with BI analyst Matt Henriksson to discuss what differentiates the Pulse IVL System from current technology to make it more flexible and durable. He also highlights first-in-human results, the next clinical milestones and the mounting market opportunity as an older demographic brings hardened lesions that require IVL technology.

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Think Surgical’s handheld robotic device miniaturizes the level of precision and accuracy orthopedic doctors expect from conventional, bigger surgical platforms, CEO Stuart Simpson explains to Bloomberg Intelligence. In this Vanguards of Health Care podcast episode, Simpson sits down with BI analyst Matt Henriksson to talk about how the company developed the TMINI robot that provides a pin driver on a gyroscopic handheld for accurate bone resection. This platform eliminates the large form factor of other systems while giving surgeons the choice of which brand of knee implant to use.

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Asensus Surgical plans to develop augmented intelligence capabilities that digitize surgery to lower variabilities during procedures, drive better results and ultimately expand the adoption of robotics, CEO Anthony Fernando says. In this episode of Bloomberg Intelligence’s Vanguards of Health Care podcast, Fernando sits down with BI health care analyst Matt Henriksson to discuss Asensus, the current barriers that keep robotic surgery’s penetration rates low and its pending acquisition by Karl Storz. Asensus’ product pathway includes the next-generation Luna robotic system, including TrueWrist 5mm instruments as well as enhancements to its Intelligent Surgical Unit.

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Artificial intelligence is touching all aspects of drug development with a lot of focus, and potential noise, on the early stages of drug discovery. In this episode of Bloomberg Intelligence’s Vanguards of Health podcast BI’s Head of Global Industries Sam Fazeli discusses the contributions of machine learning, AI and AlphaFold 3 in drug discovery with Harren Jhoti, cofounder of Astex in 1999. Jhoti remains CEO of the group as part of Otsuka Pharmaceuticals. Astex’s pioneering work in fragment-based drug discovery has lead to three marketed oncology drugs, including Novartis’ Kisqali used for breast cancer. We delve into the steps in which AI can have meaningful impact and what this may mean for saving time in drug development and reducing the risk of drug failure.

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