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In this episode we discuss suzetrigine, a novel, non-opioid pain medication that specifically targets the NaV1.8 sodium channel to manage acute pain. The document explores its pharmacological mechanisms, highlighting how it blocks pain signals without causing the addictive or severe side effects associated with traditional opioids like respiratory depression or sedation. It reviews preclinical findings and clinical trial results, showcasing suzetrigine’s effectiveness in reducing postoperative pain with a favorable safety profile. The manuscript concludes by discussing suzetrigine’s potential to address the opioid crisis by providing a safer alternative for pain management, while also emphasizing the need for further research into its long-term applications.

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This episode examines Hypertrophic Pulmonary Osteoarthropathy (HPO), a rare syndrome often associated with underlying pulmonary malignancies. It outlines HPO's clinical presentation, which includes digital clubbing and painful, swollen joints, emphasizing the importance of differentiating it from metastatic bone pain due to its bilateral and symmetrical nature on bone scans. The text further explores the proposed pathophysiological mechanisms, particularly the roles of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF). Finally, it discusses treatment strategies, highlighting that addressing the underlying disease is most effective, but also suggesting symptomatic relief options such as bisphosphonates, octreotide, and anti-inflammatory drugs for patients not amenable to primary disease treatment.

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In this episode, we discuss a complex ethical dilemma concerning a pregnant woman diagnosed with advanced ovarian cancer who refuses recommended termination and chemotherapy due to prior fertility struggles. Several experts in medicine, ethics, law, spiritual care, and social work provide differing perspectives on the case. The medical oncology perspective discusses the individualized management of cancer during pregnancy, while the ethics perspective grapples with patient autonomy versus the potential harm to both mother and fetus. The legal and social work perspectives emphasize the patient's right to self-determination. Ultimately, the article advocates for a multidisciplinary approach that respects the patient's wishes while providing comprehensive support and information. It highlights the need for healthcare providers to navigate these difficult situations with compassion and discernment.

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Thank you for your interest in Ethics in Palliative Medicine! Follow us at https://epionepalliative.com and on X: @PallCareEthics