In January, 1997, David Nierenberg was a physician at Dartmouth‐Hitchcock Medical Center, specializing in toxicology. Chemist Karen Wetterhahn was placed in his care. When she arrived at the hospital, Karen was slurring her speech and having difficulty balancing and with coordination. What David soon learned was that her symptoms were all due to a few tiny drops of a compound called dimethylmercury. Today’s episode focuses on two lab accidents that had a profound impact on research communities, and that inspired changes that have likely saved the lives of scientists and other workers since. The first story is that of Karen Wetterhahn who, in the 1990s was a professor of chemistry at Dartmouth College whose lab focused on heavy metal toxicity. The other story is about fatal prion protein exposures in France that led to a temporary moratorium in 2021.

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Climate change has brought forth extreme fire events, like the Palisade and Eaton fires in Los Angeles, which devastated communities in Altadena and the Pacific Palisades in the beginning of 2025. And it’s becoming harder to not wonder: Is this just the world we live in now? Under the constant threat of catastrophic fires? Fortunately, we have the perfect guests to answer that question. We traveled to NASA’s Goddard Space Flight Center and spoke with two of their scientists who study fires from space.

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In this episode of Tiny Show and Tell Us, we talk about why the FDA recently banned Red Dye No. 3 and how concerned people should be about its use in food. Then we cover icy winter roads and the fascinating science behind clearing them and taking a more sustainable approach that won’t hurt the environment.

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In 1975, NASA launched two spacecraft to Mars. Viking 1 and Viking 2 arrived at their destination less than a year later, each bringing a lander to explore the surface of the planet and an orbiter to survey above. What was supposed to be a 90 day mission ended up lasting until the early 1980s. Those years provided scientists with important data about the Martian landscape, from seismometer readings of marsquakes to the reddish color of the sky.

But the Viking missions had another important task: they were going to look for possible signs of life. The Viking experiments would go on to become an important landmark in science, one that’s helped researchers in a number of fields figure out what we can be doing better to find signs of life beyond Earth.

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In this episode of Tiny Show and Tell Us, we talk about what dark energy and dark matter are made out of and how knowing more could upend our understanding of the Big Bang. Then we cover microchimeric cells — cells transferred between baby and mom — and how new research in mice shows that fetal cells that took residency in mom from a first pregnancy are replaced by new fetal cells of a second pregnancy.

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In December 2017, the FDA approved a new injectable drug to treat type 2 diabetes called semaglutide, which you likely know by its brand name: Ozempic. A few years later, during the pandemic, Wegovy, a drug with a higher dose of the same active ingredient, was approved specifically for chronic weight management. Soon after, people taking Ozempic started reporting a dramatic, even “life-changing” weight loss. Ozempic is now a bona fide blockbuster. So what’s the science behind these “wonder drugs” that apparently 1 in 10 of us could end up using? They have the potential to have so many positive effects on our lives, from treating Alzheimer’s disease and addiction to changing our relationship with consumption but, like with most things, they also come with risks.

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In this episode of Tiny Show and Tell Us, we hear from a listener who has Marfan syndrome and dive into the complexities of the disease. Then we talk about pathogens that eat — or infiltrate! — plant DNA.

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