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Welcome to a brand new episode of The Uprising Show! In this episode, host Vivek Nanda sits down with Dr. Jake Kantrowitz, internal medicine physician, entrepreneur, and co-founder of River Records. Jake shares his journey from an early fascination with computer science at Milton Academy to pursuing both medicine and technology through an MD/PhD program at Boston University. Together, they unpack the genesis of River Records, a healthcare tech startup on a mission to transform how clinicians manage and access patient information using natural language processing and AI.

Jake dives into the complexity of healthcare information systems, explaining how current electronic health records often fall short for physicians and how River Records is flipping the script to build truly clinician-friendly workflows. He talks candidly about the challenges of bringing new tech to such a regulated, tradition-bound industry and why starting with smaller practices, rather than giant health systems, is a smarter path for disruptive startups.

The discussion also takes a forward-looking turn as Jake and Jasen explore the future of medical education in the age of AI, the changing role of physicians, and how new technology can empower—rather than replace—human connection in patient care. Jake even shares a few lighter personal insights, including his passion for bread baking and his favorite college squash memories.

Tune in for a thought-provoking conversation about medicine, entrepreneurship, and the human side of healthcare innovation!

Timestamps:

00:00 Inquisitive Family Man

06:10 Automating Clinical Data Summarization

08:24 Startup Pursuing Medical Data Solutions

12:26 Diverse Clinician Support Vital

14:53 Creating Generalized Clinical Tools

19:23 Streamlining Patient Records by Problem

23:47 Flaws in Problem-Oriented Charting

27:59 EHR: Challenges in Patient Engagement

30:17 "Communication Failure in Health Records"

32:15 Healthcare Data Management Challenge

36:24 Improving Patient Communication System

39:17 Evolving Medical Knowledge Evaluation

44:29 AI in Medicine: Human Touch Essential

46:11 "Guiding Medical Trainees with AI"

50:09 College Squash Varsity Experience

The Uprising Show Website: https://theuprisingshow.com/

Vivek Nanda's LinkedIn: https://www.linkedin.com/in/viveknanda1/

Vivek Nanda's Twitter: https://x.com/vickks

TopHealth Media Website: https://tophealth.care/

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In this episode of The Uprising Show, host Vivek sits down with Manush Saydmohammed, Ph.D., MBA, co-founder and CEO of ZEGENEX Inc., a Pittsburgh-based startup developing innovative wound healing solutions. Manush shares his remarkable journey from humble beginnings in Kerala, India, through a career in biomedical research across India, Japan, and the US, to becoming an entrepreneur driven by the desire to translate cutting-edge science into real-world medical solutions.

The conversation dives into how the COVID-19 pandemic inspired Manush to transition from academic research to the world of startups, and explores the science behind ZEGENEX’s groundbreaking small-molecule cream designed to accelerate healing in chronic wounds like diabetic foot ulcers. Manush candidly discusses the challenges of moving novel therapies from the lab to the clinic, the importance of patents and collaboration, and the regulatory hurdles unique to new drug entities.

They also touch on the exciting future of health tech, from AI-accelerated drug discovery to gene editing and personalized medicine. Manush closes by sharing personal insights on entrepreneurship, including the importance of mindset, adaptability, and the inspiration he draws from innovators like Mark Cuban. Whether you’re passionate about science, startups, or healthcare innovation, this episode offers an inspiring look into the entrepreneurial journey and the potential to make a real impact in patient care.

Timestamps:

00:00 From Kerala to the US: Research Journey

04:24 Navigating Transitional Unlearning

07:08 Pioneering Treatment for Chronic Wounds

11:44 Product Success: Feasibility and Viability

16:04 Zebrafish: Ideal Heart Regeneration Model

19:45 Patents Ensure Product Credibility

22:43 New Drug Device Regulatory Pathway

26:46 AI in Drug Discovery

30:27 Stem Cell Industry Exploration

31:33 Diabetic Foot Ulcer Study Phases

36:50 Change Habits, Mark Cuban Inspiration

38:30 "Challenging Fundraising, Hopeful Future"

The Uprising Show Website: https://theuprisingshow.com/

Vivek Nanda's LinkedIn: https://www.linkedin.com/in/viveknanda1/

Vivek Nanda's Twitter: https://x.com/vickks

TopHealth Media Website: https://tophealth.care/

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Welcome back! In this episode, we sit down with Scott Chetham, CEO and co-founder of Faro Health, for an in-depth conversation about revolutionizing clinical trials with data-driven technology. Scott shares his unexpected journey from Australia’s Gold Coast to becoming a healthcare tech leader in San Diego, and how his upbringing, shaped by his parents’ perseverance and partnership, inspired his approach to entrepreneurship.

In this conversation, Scott digs into the complexities of clinical trial design and the inefficiencies plaguing the industry, especially the over-reliance on outdated tools like Microsoft Word. Discover how Faro Health is modernizing the way trials are designed and managed, harnessing AI and automation to reduce costs, accelerate timelines, and improve patient experiences. Scott offers candid insights into the real problems facing pharma companies and hospital systems today and provides a behind-the-scenes look at building an innovative SaaS business in such a highly regulated space.

Whether you’re curious about the future of drug development, the role of generative AI in healthcare, or what it really takes to build a company that is changing the status quo, this episode is packed with personal stories, expert opinions, and actionable takeaways. Plus, you’ll learn why Scott’s not likely to talk cricket—despite his Aussie roots.

Tune in for an episode that’s both thought-provoking and genuinely inspiring!

Timestamps:

00:00 "Legacy of Freedom and Surprise"

05:19 Trailblazing Career and Educational Impact

06:44 Cardiac Electrophysiology Journey

13:12 "Complexity's Role in Trial Failure"

14:09 Streamlining Vaccine Design with Data

20:07 Accelerating Genome Editing Processes

22:10 Trial Data Preventing Pediatric Failures

25:28 Innovative Trial Design Insights

28:16 Outdated Clinical Trials Persist

32:53 US vs Europe: Payment & Regulation

38:14 Streamlining Drug Development Timelines

41:02 Startup's Rapid Growth Journey

43:42 Nuances in Medical Writing Explained

45:59 Documentation Workflow Experience

50:14 Insights on Clinical Trials and Investing

The Uprising Show Website: https://theuprisingshow.com/

Vivek Nanda's LinkedIn: https://www.linkedin.com/in/viveknanda1/

Vivek Nanda's Twitter: https://x.com/vickks

TopHealth Media Website: https://tophealth.care/