This study compares osteitis condensans ilii (OCI) and axial spondyloarthritis (axSpA), focusing on their clinical, laboratory, and MRI characteristics. Researchers found that OCI predominantly affects women and lacks the inflammatory markers typical of axSpA. While both conditions can present with sacroiliac joint osteitis on MRI, OCI shows anterior localization and an absence of erosions, distinguishing it from axSpA. The study highlights the challenges in differentiating these conditions and emphasizes the need for comprehensive clinical and imaging assessment. The findings provide valuable information for the differential diagnosis of these two conditions.

This episode is based on Poddubnyy D, et al. Rheumatology (Oxford) 2020;59(12):3798-3806.

and developed with NotebookLM.

This episode focuses on a randomized, placebo-controlled trial that evaluated the efficacy of infliximab, a tumor necrosis factor (TNF) inhibitor, in alleviating chronic low back pain in patients with Modic type 1 changes (degenerative disc disease with bone marrow edema) identified on magnetic resonance imaging (MRI). The results indicate that TNF blockade is not effective for this condition.

This podcast is based on the publication by Gjefsen E, et al (2024)

and was developed with NotebookLM.

This article presents expert consensus recommendations for diagnosing and treating chronic non-bacterial osteitis (CNO) in adults. A systematic review of existing literature and a multidisciplinary expert panel informed the creation of a standardized disease definition and proposed the term "CNO" to replace previous, less precise terminology. The recommendations cover diagnostic imaging, laboratory testing, and a tiered treatment approach starting with NSAIDs and moving to intravenous bisphosphonates or TNF-α inhibitors as needed. Long-term follow-up and a multidisciplinary care team are emphasized, along with a research agenda to improve understanding and treatment of this rare condition.