Dean Karnazes is a force of nature and an inspiration. He’s raced across the globe in support of various causes and modeled unparalleled perseverance and going beyond perceived limitations that serve to unlock an inner strength in others to also attain extraordinary results. He shares real-life examples that explore the topics of dealing with adversity, overcoming obstacles, setting and reaching lofty goals, the importance of teamwork - even in solo endeavors, and excelling in a competitive and complicated world. In this episode we discuss the essential ingredients necessary for high-achievement/performance and developing the ability to prevail and preserve against staggering odds.

He is also a New York Times bestselling author of a number of books, and Dean has served as a US Athlete Ambassador on three separate Sports Diplomacy envoys to Central Asia and South America. He’s twice carried the Olympic Torch and is a recipient of the President’s Council on Sports, Fitness and Nutrition’s Lifetime Achievement Award. He currently serves as the Global Ambassador of Greek Tourism.

Dean has been named Competitor magazine’s Endurance Athlete of the Year on three occasions; Men’s Fitness hailed him as one of the fittest men on the planet, and GQ magazine called him, “The Perfect Human.” ESPN awarded him an ESPY as "Best Outdoor Athlete" of the year; Men's Journal inducted him into their Adventure Hall of Fame, and Outside magazine named him one of the Ultimate Top 10 Outdoor Athletes, and put him on the cover. He’s also been on the covers of Runner’s World and Wired; and TIME magazine named him one of the “100 Most Influential People in the World.”

Dean not only lives his life in full, but he is an inspiration to millions over multiple generations, always with a gentlemanly presence, grace and gratitude, as a model for others to do so as well. He is uniquely able to demonstrate how the lessons learned from athletics can be applied to business and life, with authenticity and humanity.

Sara Fix is a powerhouse. A mother of three, a small business owner, and a woman who’s navigated life’s highs and lows—all while completing 28 Ironman races across the globe, but her biggest challenge is being diagnosed with stage 4 neuroendocrine cancer, yet, she refuses to let her diagnosis define her. She continues to train, compete, and inspire others with her resilience and positive mindset.

Sara's story is one of perseverance and advocacy. She emphasizes the importance of being one's own health advocate and encourages others to listen to their bodies and seek help when needed. Her message of hope and determination resonates with many, making her a beloved figure in the endurance sports community and beyond as she lives her life in full.

Prescription medications are fairly controversial these days – cost, insurance coverage, efficacy, and too often, medications are dosed incorrectly, cause toxic side effects or just don't work. But what if we could change how we prescribe drugs, what if there was a 3D printer that could design pills that adapt to an individual’s needs, and maybe print-on-demand the medications tailored to the patient?

Or what if there was a real-world device that worked like the diagnostic Tricorder we imagined watching Star Trek? How about AI-infused antiviral discoveries and laboratory-level diagnostic tools accessible via your smartphone?

These ideas and technologies, and many more, are paving the way to a more democratized, connected and data-driven future of medicine, and personalized care. And this is the world where Dr. Daniel Kraft thrives.

Daniel is a Stanford and Harvard trained physician-scientist with more than 25 years of experience in clinical practice, biomedical research, and innovation. He is Founder and Chair for NextMed.Health, a program which explores convergent, rapidly developing technologies and their potential to reshape the future of health and biomedicine, and he is the Faculty Chair for Medicine at Singularity University.

I’m not sure if we can call Daniel a medical futurist, as he seems to be a co-creator of that future, but I asked about what some of the various technologies transforming patient care in the next decade may be, as well as some of the exciting innovations he’s seen in regenerative medicine and stem cell therapies recently. Daniel had a great deal to say about his thoughts on that vis-à-vis personalized medicine.

We wrapped up with Daniel sharing who’s influenced you him and his work, and the various mentors he had in his various areas of interest. He also shared advice for young medical professionals interested in innovation and entrepreneurship. Daniel’s work and life are a testament to the benefit that cross-disciplinary approaches, augmented by technological innovations, can bring to medicine and healthcare. While Daniel’s work saves lives, he also serves as an inspiration for all of us to live our lives more fully.

How many Mondays do you have left?

Statistically, we all get about 4,000 Mondays in our lifetime, so if you're halfway through your life, you might have roughly 2,000 Mondays to go. The good news is that you are in charge of how you spend those days, the question is will you be toiling away at a job that you hate, or will you be creating a career that you love? Will you choose to scroll mindlessly for hours a day, or will you pursue hobbies and travel that light you up? Will you be dreading the inevitable end, or will you be living your life in full in a way that allows you to meet the Grim Reaper with a smile?

These are the existential ponderances in which Jodi Wellman thrives. Jodi is a speaker, author, executive coach, and facilitator of living lives worth living. She founded Four Thousand Mondays to help people make the most of the time they are lucky to be above ground.

Jodi has a Master's of Applied Positive Psychology from the University of Pennsylvania, where she is also an Assistant Instructor and facilitator in the Penn Resilience Program. She is an ICF Professional Certified Coach and a Certified Professional Co-Active Coach. Jodi has been featured in The New York Times, Oprah Daily, Fast Company, CNBC, Forbes, Psychology Today, and The Los Angeles Times, to just name a few. Jodi's TEDx talk, How Death Can Bring You Back to Life, has over 1.3 million views and was the 14th most-watched TEDx talk in 2022.

Her new book, You Only Die Once: How to Make It to the End with No Regrets, made Adam Grant's Summer Reading List, is a Next Big Idea Club must-read.

Jodi’s book, work, and life show us all how we can gain a newfound appreciation for our lives and prioritize what truly matters. Her book uses a blend of research, personal anecdotes, and practical exercises all done with a sharp sense of humor that guides us through self-assessment, habit identification, and action planning, encouraging us to break free from routine, discover our passions, and live a life in full - brimming with vitality and purpose.

I suspect that there are times you may feel overwhelmed by the sheer number and complexity of nonstop decisions you need to make. To further complicate matters, you may believe that some decisions require rational (brain) decision making, while others call for you to "go with your gut." But what if you could integrate the two - your brain and your gut - in a way to help you become the calm and steadfast person, and leader, you would like to be. What if you could combine both rational logical thoughts with your more instinctual feelings?

With their combined expertise in both business and medicine, Drs. Geoffrey VanderPal and Randy Brazie have developed an approach to do just that - by taking the latest scientific understanding of the human nervous system, drawing upon the Polyvagal Theory, to understand how the brain and the gut can make decisions together.

In their new book, The Steadfast Leader: Control Anxiety, Make Confident Decisions, and Focus Your Team Using the New Science of Leadership, they provide an approach that shifts away from the tension caused by "either-or" to using "both-and" and how that works better in every situation. Their work provides fascinating research findings along with real-world case studies and relatable examples that demonstrate practical, cutting-edge neuroscientific concepts that can help you stay focused and make better decisions―for yourself, your team, and your organization

Drs. Brazie and VanderPal are pioneers in the application of the Polyvagal Theory’s application in not only leadership and business situations, but also to each of us as individuals as a means to forge deeper and more authentic connections and relationships. In doing so it provides another approach for all of us to use as a way to help us live our lives more fully, and make better decisions.

Life depends on learning. We spend decades in school acquiring an education. We take pride in mastering a craft, or a sport, or a game. The things we do in our careers or even just for fun are enjoyed to a large extent because we feel we are capable of getting better at them.

We yearn for mastery.

But learning can be elusive. We may spend hours studying and still not do well on an exam. Improvement can be fickle - if it comes at all. Sometimes we improve effortlessly, and other times it can be a slog. Many of us can spend years hitting a tennis ball, playing chess, or working at our jobs, and not reliably get better at any of them. Why is that and more importantly, what can be done?

In Scott Young’s new book, Get Better at Anything: 12 Maxims for Mastery, he explores the science of skill acquisition, illustrating the basic principles that can help us get better at the things that matter most.

Scott was a prior guest on the show in episode 37 when we discussed his Wall Street Journal bestseller Ultralearning. He is also a podcast host and, a computer programmer. Since 2006, he has published weekly essays to help people learn and think better. His work has been featured in the New York Times, Pocket, and Business Insider, on the BBC, and at TEDx.

While he doesn’t promise to have all the answers, he does give us a good place to start.

Scott is a wellspring of knowledge about learning and provides a way for us all to be able to live our lives more fully.

It seems that almost everywhere in the world, there is conflict, distrust, and unrest – Gaza, Ukraine, Syria, and even here in the US. Oftentimes, any kind of diplomacy, cooperation, agreement, detente or finding a common ground seems impossible. But what if there was a different way? What if there was an organization that holds as its mission, “to transform the way the world deals with conflict, away from adversarial approaches and toward cooperative solutions?” What if those tactics included dialogue training, joint development projects, public art projects, sports leagues, and social impact entertainment via radio, TV, film, and print?

Well, these are all accomplishments that John Marks has achieved in his work as President of Search for Common Ground, a peacebuilding NGO he founded in 1982 and built with his wife Susan Collin Marks, predicated on social entrepreneurship.

He is the coauthor of the controversial New York Times best-seller The CIA and the Cult of Intelligence, the award-winning Search for the “Manchurian Candidate,” and we’ll be doing a deep dive into his latest book, From Vision to Action: Remaking the World Through Social Entrepreneurship, just recently published by Columbia University Press.

John is also a Skoll Awardee in Social Entrepreneurship and an Ashoka Senior Fellow. The UN’s University of Peace awarded him an honorary doctorate for is work, and in 2018, Search for Common Ground was nominated for the Nobel Peace Prize.

I found From Vision to Action to be both a memoir and somewhat of a practitioner’s guide to the underlying principles of social entrepreneurship. It offers a master class in effective negotiation and conflict resolution. It builds on a core strategy of understanding differences and acting on commonalities. John uses his own experiences of creating real-life breakthroughs during his time leading Search for Common Ground.

John’s pioneering work has genuinely made the world a safer and better place for us all – he is an inspiration.

We are not as smart as we think we are.

We're busy and distracted in a world that is incentivized to continually make us more of both. The only things that work, the only messages that cut through the noise, are sharp, clear, and direct.

We’ve all been advised to “not judge a book by its cover,” to “not count your chickens before they hatch,” and that “Rome wasn’t built in a day.” Maybe for you, what comes to mind is something political, like Patrick Henry’s revolutionary “Give me liberty, or give me death!” or more recently, Barack Obama’s “Yes We Can.”

Now think for a second about the other few thousand messages you heard in the past 24 hours –things told to you, like ads, warnings, instructions, or even things you’ve sought out, like articles, social media posts, or stories.

How many of them do you actually remember? How many of the things that you’ve said, do other people remember? Do they actually even hear what you’re saying?

The answer is simple. Literally. Simple. Regardless if these messages are trying to get your dollars, your votes, or just your thoughts, the most effective messages all share one thing. They-are-simple.

Ben Guttmann is interested in the things and ideas that move people - why we make the decisions we make; why we vote for who we vote for; why we buy the products we buy, and ultimately, why we do what we do.

We did a deep dive into his new book, Simply Put: Why Clear Messages Win-and How to Design Them. It emphasizes the importance of clear communication, and we discussed why he believes clarity is such a critical skill, both personally and professionally. Simply Put offers strategies for simplifying complex ideas and messages. Ben stepped me through the key principles and techniques listeners can use to streamline their communication effectively.

It was a fun and informative conversation with one of the best. Ben’s work is a gift to not only his students, but to all of us who want to communicate more clearly, and simply.