You picked the right drug. The culture said susceptible.
And the infection still got worse.

It’s not always resistance — sometimes, it’s you.

In this episode, we break down how antimicrobials actually kill — and why understanding that is the key to board success and clinical results.

You’ll learn:

• The difference between bactericidal and bacteriostatic drugs
• The mechanisms of action for the major antimicrobial classes
• Why folic acid synthesis inhibition is a double-drug strategy
• How to choose the right kill style for the right patient
• Time-dependent vs. concentration-dependent antibiotics

Includes a board-style question + flashcard-style recap.

🎧 Built for surgical residents.
Feedback or requests? cd@simini.com

In this episode, we break down one of the most misunderstood principles in fracture repair: what role your implant is actually playing.

Is it carrying all the load? Or sharing it with the bone?
Because if you mismatch your construct to the fracture — it’s not if it will fail. It’s when.

🔍 You’ll learn:

• The difference between load sharing and load bearing
• What happens when implants are too stiff or too weak
• When to use bridging vs. compression
• Why implant selection = healing environment
• Common board traps, like over-stiff constructs and stress shielding

Includes a board-style question + flashcard recap. Built for residents.

🎧 Listen while commuting, scrubbing in, or running with your dog.

Feedback? Ideas for the next episode? cd@simini.com

What actually heals a fracture — the metal or the biology? In this episode, we break down the real mechanics of bone healing, and why even textbook-perfect plates can fail if the strain environment isn’t right.

You’ll learn:

• The difference between primary and secondary bone healing
• Why interfragmentary strain (IFS) controls tissue differentiation
• How to match fixation strategy to fracture type
• What constructs fail and why — and how to avoid it

Includes a board-style question, a flashcard recap, and a few “don’t make this mistake” moments.

🎧 Built for surgical residents. Backed by Tobias.
🔍 Powered by Simini + AI, fine-tuned for board prep.

🚨 Feedback? Ideas for the next episode? Email cd@simini.com