『Healio Rheuminations』のカバーアート

Healio Rheuminations

Healio Rheuminations

著者： Adam J. Brown MD
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 Rheumatology is an incredibly fast-moving and exciting field of medicine that can be difficult to keep up with. This Healio podcast provides busy clinicians with quick updates in the field of autoimmunity, with emphasis on new medications, treatment guidelines and explorations into the pathophysiology of diseases. The show will also feature historical perspectives in the field of rheumatology, as well as fascinating case presentations of medical mysteries complete with discussions from experts in the field. 生物科学 科学 衛生・健康的な生活 身体的病い・疾患
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  • The Astounding Account of the IL-17 and Spondylarthritis

    The Astounding Account of the IL-17 and Spondylarthritis
    2025/07/28
    In this episode, we focus on the history of researchers discovering the clinical applicability of the IL 23/17 axis, with a particular emphasis on psoriasis, psoriatic arthritis and axial SpA · Intro 0:01 · In this episode 0:12 · Leonard Calabrese, DO, is listening! 0:54 · Recap of last episode 3:09 · Putting the pieces together 5:12 · Quick overview of this science heavy episode 6:11 · What is psoriasis? 7:26 · Immunosuppressants for psoriasis/ Throwing meds at people and seeing what happens 10:10 · In the modern world of 1986 – olive oil placebo trial 11:36 · A quick aside into fungi 12:35 · What kind of T-cells are involved here? 16:41 · The TH-1 hypothesis 18:20 · IL-23 and IL-17 are doing something 19:34 · Going back to the drawing board in 2004 20:00 · p40 + p19 = IL-23 21:00 · IL-23 via minicircle DNA in mice 23:05 · Brand new and shiny TH-17 25:23 · The family of IL-17 26:36 · What do we know about IL-17 and psoriasis? 27:10 · IL-17A vs IL-17F in mouse studies 27:35 · Finding the difference between IL-17A and IL-17F in humans 28:23 · What exactly is IL-17 doing? 29:30 · The articular manifestations of psoriatic arthritis 30:57 · Spondylarthritis and the IL 23/17 axis 33:56 · T-cells we haven’t talked about 35:40 · Summary of this episode 39:08 · Thanks for listening 41:34 We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Bashyam H. J Exp Med. 2007;doi:10.1084/jem.2042fta Bjerke R J. Acta Derm Venereol. 1982;PMID:6179355 Cargill M, et al. Am J Hum Genet. 2007;doi:10.1086/511051 Chan J R, et al. J Exp Med. 2006;doi:10.1084/jem.20060244 Cuthbert R J, et al. Ann Rheum Dis. 2019;doi:10.1136/annrheumdis-2019-215210 Ellis C N, et al. JAMA. 1986;doi:10.1001/jama.1986​ Ettehadi P, et al. Clin Exp Immunol. 1994;doi:10.1111/j.1365-2249.1994.tb06244.x Furue M, et al. Int J Mol Sci. 2020;doi:10.3390/ijms21041275 Gooderham M J, et al. J Eur Acad Dermatol Venereol. 2018;doi:10.1111/jdv.14868 Lee E, et al. J Exp Med. 2004;doi:10.1084/jem.20030451 Leonardi C L, et al. Lancet. 2008;doi:10.1016/S0140-6736(08)60725-4 Mease P J, et al. Lancet. 2000;doi:10.1016/S0140-6736(00)02530-7 Menon B, et al. Arthritis Rheumatol. 2014;doi:10.1002/art.38376 Moos S, et al. J Invest Dermatol. 2019;doi:10.1016/j.jid.2019.01.006 Muelle W, et al. N Engl J Med. 1979;doi:10.1056/NEJM197909063011016 Papp K A, et al. Lancet. 2008;doi:10.1016/S0140-6736(08)60726-6 Reinhardt A, et al. Arthritis Rheumatol. 2016;doi:10.1002/art.39732 Sherlock J P, et al. Nat Med. 2012;doi:10.1038/nm.2817 Tribe H T. Mycologist. 1998;doi:10.1016/S0269-915X(98)80100-6 Yawalkar N, et al. J Invest Dermatol. 1998;doi:10.1046/j.1523-1747.1998.00446.x Zaba L C, et al. J Allergy Clin Immunol. 2009;doi:10.1016/j.jaci.2009.08.046 Disclosures: Brown reports no relevant financial disclosures.
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    42 分
  • The Tumultuous Tale of Th17-and the IL23/IL17 immune axis

    The Tumultuous Tale of Th17-and the IL23/IL17 immune axis
    2025/06/30

    In this episode, we dive into a two-part story of intrigue starting from a paradigm shift in understanding of T cell biology because of a mouse model of post-measles encephalopathy, to the eventual recognition of the IL-23/17 immune axis.

    • Intro 0:01
    • In this episode 0:12
    • Interleukin-17 (IL-17) is a relatively recent discovery 1:34
    • The beginning of TH-17 2:20
    • Looking at autoimmune encephalopathy: A story of measles 03:30
    • 1790’s woman with post measles inflammatory process in the brain 10:26
    • What is causing post-infection encephalitis? 12:00
    • Acute disseminated encephalomyelitis 12:30
    • How did we find out the immune system was behind this - The rabies vaccine 13:09
    • Similarity between the rabies vaccine and infections like measles 16:04
    • T-cell lymphocytes 17:12
    • The forgotten thymus 18:00
    • What’s the function of T-cells? 19:35
    • How do you tell T-cells apart? 21:14
    • The Human Leukocyte Differentiation Antigens Party 24:05
    • The godfather of T-cells 24:45
    • The TH-1 and TH-2 axis 27:30
    • Experimental Autoimmune Encephalomyelitis model screwed everything up 29:16
    • Interferon gamma 32:32
    • What’s missing? IL-23 surprise 33:40
    • IL-17 in the 1990’s 36:44
    • The world is introduced to TH-17 39:12
    • Let’s recap what we learned 40:30
    • That is the end! 42:30
    • Thanks for listening 42:39

    We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.


    References:

    Bashyam H. J Exp Med. 2007;doi:10.1084/jem.2042fta

    Bennetto L, et al. J Neurol Neurosurg Psychiatry. 2004;doi:10.1136/jnnp.2003.034256

    Berche P. Presse Med. 2022;doi:10.1016/j.lpm.2022.104149

    El-behi M, et al. J Neuroimmune Pharmacol. 2010;doi:10.1007/s11481-009-9188-9

    Gooderham MJ, et al. J Eur Acad Dermatol Venereol. 2018;doi:10.1111/jdv.14868

    Hawkes JE, et al. J Immunol. 2018;doi:10.4049/jimmunol.1800013

    Rogozynski N, et al. Immunol Lett. 2024;doi:10.1016/j.imlet.2024.106870

    Sospedra M, et al. Annu Rev Immunol. 2005;doi:10.1146/annurev.immunol.23.021704.115707

    Steinman L. Nat Med. 2007;doi:10.1038/nm1551

    Disclosures: Brown reports no relevant financial disclosures.
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    43 分
  • History of polymyalgia rheumatica: The origin of the pain & link to giant cell arteritis

    History of polymyalgia rheumatica: The origin of the pain & link to giant cell arteritis
    2025/05/30

    In this episode, we dive into the history of polymyalgia rheumatica, how it was discovered and its link to giant cell arteritis.

    • Intro 0:01
    • In this episode 0:10
    • What is polymyalgia rheumatica (PMR)? 0:24
    • The history of PMR 02:12
    • PMR in the 1950s: A formally recognized disease 04:52
    • What was probably PMR in the 1880s 06:27
    • Naming PMR: Senile rheumatic gout 07:26
    • 1957: The witch’s shot and finally landing on polymyalgia rheumatica 08:30
    • Where is PMR coming from? 14:42
    • Injecting joins with saline 16:39
    • A biopsy study in 1964 19:54
    • Technetium bone scintigraphy in 1971 and bone scan history 23:01
    • First look at a PMR ultrasound in 1993 27:00
    • 1997: First use of MRI on PMR patients in Italy 27:49
    • Going back to 1962: PMRs association with giant cell arteritis 30:40
    • A paper on muscular involvement in giant cell arteritis: 80-year-old ‘robust’ partially blind seaman 32:15
    • First systematic approach: The link between PMR and giant cell arteritis 35:14
    • 80 cases of PMR 38:13
    • Swedish autopsy studies 41:07
    • Introduction of advanced imaging in the 1990s 42:40
    • Summing up PMR through the decades 43:28
    • That is the end! 45:25
    • Thanks for listening 45:50

    We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

    References:
    Bruk MI. Ann Rheum Dis. 1967;doi:10.1136/ard.26.2.103.
    Cantini F, et al. J Rheumatol. 2001;28(5):1049-55.
    De Miguel E, et al. Rheumatology (Oxford). 2024;doi:10.1093/rheumatology/kead189.
    Dixon AS, et al. Ann Rheum Dis. 1966;doi:10.1136/ard.25.3.203.
    Hamrin B, et al. Ann Rheum Dis. 1968;doi:10.1136/ard.27.5.397.
    Salvarani C, et al. Ann Intern Med. 1997;doi:10.7326/0003-4819-127-1-199707010-00005.
    Shah S, et al. Rheumatology (Oxford). 2025;doi:10.1093/rheumatology/keae569.

    Disclosures: Brown reports no relevant financial disclosures.
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    46 分
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