Ozempic has been hailed as a miracle drug. It is the most well known of the GLP-1 medications, a class of drugs that can help regulate appetite, digestion, and blood sugar—and help those suffering from obesity or diabetes lose weight. Naturally, these drugs are very much in demand. But now there is a shortage of Ozempic and other GLP-1s, which has led to a swell of clones that purport to offer the same benefits and the same key ingredient, semaglutide, at lower prices. These clone drugs are easy to procure from telehealth providers, even if a buyer needs to lie about themselves a little bit to buy them.

In this brave new weight-loss world, we're still coming to grips with how these drugs fit into our society. Part of that journey is the continued study about how GLP-1 drugs work—much of how they affect us is still unknown—and the continued debate about how much we should regulate and control their use.

This week on Gadget Lab, we talk with WIRED writers Kate Knibbs and Emily Mullin about how GLP-1 medications like Ozempic work and what happens when they don’t. We also talk about the current drug shortage and how that may get resolved.

This episode originally aired July 11, 2024. Read the transcript.

Show Notes:

Read Kate’s story about buying cloned Ozempic online. Read Emily’s story about how Ozempic doesn’t work for everyone. Read all the stories in WIRED’s The Age of Ozempic series.

Recommendations:

Emily recommends staying cool this summer however you can. Kate recommends the HBO series John Adams, starring Paul Giamatti. Mike recommends buying a used 35-mm film camera and shooting some rolls to flex your creativity.

Kate Knibbs can be found on social media @Knibbs. Emily Mullin is @emilylmullin. Michael Calore is @snackfight. Lauren Goode is @LaurenGoode. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys.

AI data centers are so hot right now. Each time generative AI services churn through their large language models to make a chatbot answer one of your questions, it takes a great deal of processing power to sift through all that data. Doing so can use massive amounts of energy, which means the proliferation of AI is raising questions about how sustainable this tech actually is and how it affects the ecosystems around it. Some companies think they have a solution: running those data centers underwater, where they can use the surrounding seawater to cool and better control the temperature of the hard working GPUs inside. But it turns out just plopping something into the ocean isn't always a foolproof plan for reducing its environmental impact.

This week on Gadget Lab, WIRED writers Paresh Dave and Reece Rogers join the show to talk about their reporting on undersea data centers and how the race to power AI systems is taking its toll on the environment.


Show Notes:
Read Paresh and Reece’s story about the plan to put an underwater data center in the San Francisco Bay. Read Reece’s stories about how this is AI’s hyper-consumption era and how to wade through all the AI hype. Read Lauren’s story about the social network inhabited only by bots. Read Karen Hao’s story in The Atlantic about how companies like Microsoft are taking water from the desert to use for cooling down AI data centers. Here’s the Black Cat substack article about the character Harper from Industry. Follow all of WIRED’s AI and climate coverage.


Recommendations:
Paresh recommends checking out cookbooks from your local library. Reece recommends the soundtrack of the first Twilight movie for all your Fall feels. Lauren recommends the HBO show Industry. Mike recommends Anna Weiner’s profile of bicycle designer Grant Peterson in The New Yorker.

Reece Rogers can be found on social media @thiccreese. Paresh Dave is @peard33. Lauren Goode is @LaurenGoode. Michael Calore is @snackfight@heads.social. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys.

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One surefire way to go viral on Threads—the Meta-owned Instagram-spinoff social network with more than 200 million users—is to ask a ridiculous question that enrages your followers so much, they just have to chime in to answer you, mock you, or berate you. When it first launched last summer, Threads was seen as a blatant Twitter clone. At the time, that was an appealing attribute, as users fleeing the platform now known as X were looking for a new place to gather. Threads turned out to be a safe haven from the trolling and engagement bait on X, Reddit, and Facebook, but only for a while. Threads, like any for-profit social media site, was not able to keep those jokers and bad actors at bay. In its effort to boost engagement on the platform, Threads began prioritizing posts with the most replies and comments—which also happen to be the posts that stirred up the most drama and pissed everyone off.
This week on Gadget Lab, we chat with Business Insider senior correspondent Katie Notopoulos about her personal experiment with rage bait immersion on Threads. We also ask whether social media sites are making the right decision by catering to their most furious users.

Show Notes:
Read Katie’s story about ragebait on Threads. Read Lauren’s story about the new app SocialAI, where the only human is you, and everyone else is a bot.

Recommendations:
Katie recommends the reality show The Secret Lives of Mormon Wives on Hulu. Mike recommends the HBO show Industry. Lauren recommends the Apple TV+ show Slow Horses.

Katie Notopolous can be found on Threads @katienotopoulos. Lauren Goode is @LaurenGoode. Michael Calore is @snackfight@heads.social. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys.

Share your thoughts on WIRED Gadget Lab. As a token of our appreciation, you will be eligible to enter a prize drawing up to $1,000 after you complete the survey.

https://selfserve.decipherinc.com/survey/selfserve/222b/76152?pin=1&uBRANDLINK=7&uCHANNELLINK=2