Welcome to the January 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the January 2025 issue of Diabetes.

2:00 In a special format for the first episode of the new year, our hosts introduce a Sweet Talk double feature.

3:35 In part one of this special Sweet Talk segment, our hosts are joined by Philipp Scherer, PhD, Professor in the Department of Internal Medicine at the University of Texas Southwestern Medical Center in Dallas, Texas, and Director of the Touchstone Diabetes Center, and Joel Elmquist, DVM, PhD, Professor of Internal Medicine at UT Southwestern Medical Center, and Director of its Center for Hypothalamic Research. Both are previous recipients of the ADA’s Outstanding Scientific Achievement Award, and Scherer recently received the ADA’s Banting Medal.

They share their perspectives on the evolution of diabetes, obesity research, the interplay between the brain and adipose tissue, and what the future holds for understanding and treating these complex diseases.

33:00 In part two, our hosts speak with Jonathan Flak, PhD, Assistant Professor of Pharmacology & Toxicology at the Indiana University School of Medicine, and former recipient of the ADA’s Pathway to Stop Diabetes Award. He discusses his work on the brain’s role in glucose regulation, energy balance, and bodyweight control.

His article, “Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes: A Report on Research Supported by Pathway to Stop Diabetes,” can be found in the January 2025 issue of Diabetes.

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the December 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2024 issue of Diabetes.

0:55 In celebrating the one-year anniversary of DiabetesBio, our hosts highlight a few of their favorite articles from the last year. These include:

• Ueki et al. Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery doi.org/10.2337/db23-0445
• Bruce et al. The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans doi.org/10.2337/db24-0388
• Furber et al. GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice doi.org/10.2337/db23-0172
• Greenbaum et al. Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop doi.org/10.2337/dbi24-0020
• Ramos et al. Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes doi.org/10.2337/db23-0827
• Bonifazi et al. Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia doi.org/10.2337/db24-0175

6:15 Darleen is joined by Lukas Stilgenbauer of the Department of Biological Sciences at Wayne State University in Detroit, Michigan, as well as Mariana Sadagurski, associate professor in the Institute of Environmental Health Sciences and Integrative Biosciences Center at Wayne State University. They discuss their article “Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling.” This article is available for free at doi.org/10.2337/db24-0110

33:45 Kirk and Kevin dive into the December issue’s Paper of the Month, “Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes.” They’re joined by lead author Max Petersen, an instructor at the Division of Endocrinology, Metabolism, & Lipid Research at Washington University School of Medicine in St. Louis, Missouri. The article is available for free at doi.org/10.2337/db24-0083.

47:20 Finally, this month’s edition of Sweet Talk focuses on work funded by the American Diabetes Association’s Pathway to Stop Diabetes initiative. Kathleen Alanna Page, Associate Professor of Medicine at the University of Southern California’s Keck School of Medicine, and Jasmin Alves, a postdoctoral research fellow with Page, stop by to discuss Page’s study, “Neurodevelopmental Pathways to Obesity and Type 2 Diabetes: Insights From Prenatal Exposure to Maternal Obesity and Gestational Diabetes Mellitus: A Report on Research Supported by Pathway to Stop Diabetes.” The article is available at doi.org/10.2337/dbi24-0012

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the November 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2024 issue of Diabetes.

3:45 After a quick rundown of our hosts' Halloween plans, this month’s episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code ‘FALL24’ at checkout. Act fast because this offer expires November 30, 2024!

5:00 Darleen and Kirk speak with Dr. Nicholas Maxwell, postdoctoral fellow at Duke University School of Medicine, and Claudia Grillo, a research associate professor in the Department of Pharmacology, Physiology, and Neuroscience at the University of Southern Carolina School of Medicine in Columbia. They are lead author and corresponding author, respectively, of the article “Leptin Activation of Dorsal Raphe Neurons Inhibits Feeding Behavior.” This article is available for free at doi.org/10.2337/db24-0207.

27:05 Our hosts discuss the November issue’s Paper of the Month, “Deciphering the Connection Between Microvascular Damage and Neurodegeneration in Early Diabetic Retinopathy.” They’re joined by senior author, Dr. Marcus Fruttiger, Professor of Experimental Ophthalmology at the Institue of Ophthalmology, University College, London. This study is available at doi.org/10.2337/db24-0107.

50:25 Finally, in honor of World Diabetes Awareness Day on November 14, as well as National Diabetes Month, this month’s Sweet Talk segment features Dr. Giles Yeo, a geneticist and obesity researcher from the University of Cambridge. Dr. Yeo discusses how genetic variations contribute to obesity, appetite control, and metabolic health.

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!