For our final episode of Season 1, I spoke with Dr. Andrew Steptoe about social relationships as we age, the need for interdisciplinary research, and emerging biomarkers of interest to stress scientists. Dr. Steptoe is both a prolific and brilliant scientist whose work has identified psychobiological pathways linking low socioeconomic status with cardiovascular disease progression. I especially enjoyed hearing Dr. Steptoe reflect on research surrounding positive well-being and health, as well as the next steps for intervention science that we need to move forward as a field. Stay tuned for Season 2 of the Stress Puzzle this Fall!

Dr. Andrew Steptoe is a Professor of Psychology and Epidemiology at University College London. He was a founding editor of the British Journal of Health Psychology. He also directs the Psychobiology Research Group and the English Longitudinal Study of Ageing (ELSA). He is one of the most impactful researchers in the field of health psychology as his work has identified crucial mechanisms through which social and psychological circumstances influence cardiovascular disease and aging. He was recently honored with the Distinguished Scientist Award from the Society for Biopsychosocial Science and Medicine. Outside of the lab, Dr. Steptoe has written on the cultural background of Mozart operas and has contributed to research on Renaissance and 18th century history. Dr. Steptoe also coedited the second edition of A Matter of Life, which is a book about how his father (Patrick Steptoe) and Robert Edwards developed the procedure for in vitro fertilisation (IVF).

Topics Discussed:

• Psychobiology
• Social Status/Socioeconomic Status
• Population Studies/Cohort Studies
• Biomarkers
• Biological Processes/Biological Aging
• Psychoneuroimmunology
• Stress Measurement
• Social Connection

Papers Mentioned:

• ELSA (English Longitudinal Study of Aging): https://www.elsa-project.ac.uk/
• Whitehall II: Marmot MG, Smith GD, Stansfeld S, Patel C, North F, Head J, White I, Brunner E, Feeney A. Health inequalities among British civil servants: the Whitehall II study. Lancet. 1991 Jun 8;337(8754):1387-93. doi: 10.1016/0140-6736(91)93068-k. PMID: 1674771.
• Hamilton, O. S., Iob, E., Ajnakina, O., Kirkbride, J. B., & Steptoe, A. (2024). Immune-neuroendocrine patterning and response to stress. A latent profile analysis in the English longitudinal study of ageing. Brain, behavior, and immunity, 115, 600–608.

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The Stress Puzzle is hosted by Dr. Ryan L. Brown (https://www.ryanlinnbrown.com/) and supported by the UCSF Stress Measurement Network, an NIH/NIA funded network which aims to better understand the relationship between stress and health by improving the measurement of stress in research studies. Learn more about available resources to support stress research at: www.stressmeasurement.org.

Have burning questions about stress? Email us at stresspuzzlepod@gmail.com and we may feature your question in a future episode!